
Melanocortin analog
PT-141
PT-141 is a cyclic heptapeptide analog of alpha-MSH, structurally derived from Melanotan-2 by replacing the terminal amide group with a carboxylic acid. In research literature, it binds to melanocortin receptors with a reported preference for MC4R and MC3R. It has been studied in models of central melanocortin signaling in rodent studies.
$1,290 MXN / unit
Mass: 10 mg
In stock · SKU PT141-10
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For laboratory research only. Not for human or veterinary use.
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Shipping termsResearch context & mechanism
MC4R is a Gs protein-coupled receptor expressed in hypothalamic nuclei. Its activation modulates cyclic AMP production in cellular models.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Molecular formula
- C50H68N14O10
- Molecular weight
- 1025.16 Da
- CAS number
- 189691-06-3
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Certificate results are accessed with your order details; if documentation is available on request, contact support before relying on it.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials.
Obstet Gynecol · 2019 · PMID 31599840
- Safety Profile of Bremelanotide Across the Clinical Development Program.
J Womens Health (Larchmt) · 2022 · PMID 35147466
- An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist.
J Sex Med · 2006 · PMID 16839319
- Structural insights into ligand recognition and activation of the melanocortin-4 receptor
Cell Res · 2021 · PMID 34433901
- Bremelanotide: an overview of preclinical CNS effects on female sexual function
J Sex Med · 2007 · PMID 17958619
- The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women
CNS Spectr · 2022 · PMID 33455598
- Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics.
J Pharm Biomed Anal · 2020 · PMID 32353679
- PT-141: a melanocortin agonist for the treatment of sexual dysfunction.
Ann N Y Acad Sci · 2003 · PMID 12851303
Frequently asked questions
How is PT-141 supplied?
PT-141 is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is PT-141 stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.


