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Pureza
KPV, 5 mg, Pureza research material

Alpha-MSH-derived tripeptide

KPV

KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, composed of lysine, proline and valine. In preclinical models, it has been described as acting on intracellular signaling pathways associated with nuclear factor kappa B, without requiring binding to melanocortin receptors. It has been investigated in models of intestinal mucosal inflammation in in vitro studies.

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$1,724 MXN / unit

Mass: 5 mg

In stock · SKU KPV-05

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For laboratory research only. Not for human or veterinary use.

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Research context & mechanism

The tripeptide retains the minimal region described for the non-pigmentary activity of alpha-MSH. Its action is studied at the intracellular level in cellular models.

Technical specifications

Reference specifications describe the material. They do not replace the analytical results for a specific batch.

Chemical name
L-lysyl-L-prolyl-L-valine
Sequence
Lys-Pro-Val
Molecular formula
C16H30N4O4
Molecular weight
342.44 Da
CAS number
67247-12-5
Form
Lyophilized powder
Appearance
White to off-white solid
Purity specification
Declared in the batch certificate
Identity
Declared in the batch certificate
Solubility
Soluble in sterile water and bacteriostatic water
Storage
−20 °C, protected from light
Stability after reconstitution
Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Batch documentation

Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Certificate results are accessed with your order details; if documentation is available on request, contact support before relying on it.

Consult batch certificates How to read documentation

Laboratory handling

Reconstitution
Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage
Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment
Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Research references

  1. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides

    J Pharmacol Exp Ther · 2003 · PMID 12750433

  2. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

    Inflamm Bowel Dis · 2008 · PMID 18092346

  3. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

    Mol Ther · 2017 · PMID 28143741

  4. Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore

    Adv Exp Med Biol · 2010 · PMID 21222263

Frequently asked questions

How is KPV supplied?

KPV is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.

How is KPV stored in the laboratory?

Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.

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