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Pureza
FOXO4-DRI, 5 mg, Pureza research material

D-retro-inverso peptide

FOXO4-DRI

FOXO4-DRI is a retro-inverso peptide synthesized with D-amino acids, designed from the interaction domain between the transcription factor FOXO4 and the protein p53. In research literature, it interferes with that protein-protein interaction in the cell nucleus. It has been investigated in models of cellular senescence in in vitro studies.

Select a variant

$3,990 MXN / unit

Mass: 5 mg

In stock · SKU FOXO-05

Prices in Mexican pesos. Cart and secure checkout are currently in Spanish. Shipping and any applicable discounts are shown before payment.

For laboratory research only. Not for human or veterinary use.

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Shipping protection included: report damage with photos within 24 hours of delivery for one replacement.

Shipping terms

Research context & mechanism

According to structural literature, FOXO4-DRI binds to the TAD2 region of p53; both the FOXO4-derived region and the cell-penetrating segment participate in the interaction. These findings describe the experimental construct.

Technical specifications

Reference specifications describe the material. They do not replace the analytical results for a specific batch.

Chemical name
D-retro-inverso peptide derived from the FOXO4-p53 interaction domain
Sequence
Not available
Molecular formula
Not available
Molecular weight
Not available
CAS number
Not available
Form
Lyophilized powder
Appearance
White to off-white solid
Purity specification
Declared in the batch certificate
Identity
Declared in the batch certificate
Solubility
Soluble in sterile water and bacteriostatic water
Storage
−20 °C, protected from light
Stability after reconstitution
Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Batch documentation

Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Certificate results are accessed with your order details; if documentation is available on request, contact support before relying on it.

Consult batch certificates How to read documentation

Laboratory handling

Reconstitution
Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage
Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment
Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Research references

  1. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

    Cell · 2017 · PMID 28340339

  2. Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.

    Naunyn Schmiedebergs Arch Pharmacol · 2026 · PMID 42024235

  3. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.

    Nat Commun · 2025 · PMID 40593617

  4. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.

    Front Bioeng Biotechnol · 2021 · PMID 33996787

Frequently asked questions

How is FOXO4-DRI supplied?

FOXO4-DRI is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.

How is FOXO4-DRI stored in the laboratory?

Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.

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