
D-retro-inverso peptide
FOXO4-DRI
FOXO4-DRI is a retro-inverso peptide synthesized with D-amino acids, designed from the interaction domain between the transcription factor FOXO4 and the protein p53. In research literature, it interferes with that protein-protein interaction in the cell nucleus. It has been investigated in models of cellular senescence in in vitro studies.
$3,990 MXN / unit
Mass: 5 mg
In stock · SKU FOXO-05
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For laboratory research only. Not for human or veterinary use.
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Shipping termsResearch context & mechanism
According to structural literature, FOXO4-DRI binds to the TAD2 region of p53; both the FOXO4-derived region and the cell-penetrating segment participate in the interaction. These findings describe the experimental construct.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- D-retro-inverso peptide derived from the FOXO4-p53 interaction domain
- Sequence
- Not available
- Molecular formula
- Not available
- Molecular weight
- Not available
- CAS number
- Not available
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Certificate results are accessed with your order details; if documentation is available on request, contact support before relying on it.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell · 2017 · PMID 28340339
- Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
Naunyn Schmiedebergs Arch Pharmacol · 2026 · PMID 42024235
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Nat Commun · 2025 · PMID 40593617
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.
Front Bioeng Biotechnol · 2021 · PMID 33996787
Frequently asked questions
How is FOXO4-DRI supplied?
FOXO4-DRI is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is FOXO4-DRI stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.
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